Scientists in Canada performed a study to discover whether Cannabis sativa extracts may assist in minimizing the levels of the host cell receptor that the SARS-CoV-2 infection sticks on to gain entry and spread.
For the research study, researchers from the University of Lethbridge and Pathway Rx Inc., Lethbridge established numerous new C. Sativa cultivars and evaluated 23 extracts in synthetic 3D human designs of the oral, respiratory tract, and digestive tissues.
The research study, released in the journal Aging, kept in mind that 13 of the extracts downregulated expression of the SARS-CoV-2 host cell receptor angiotensin-converting enzyme 2 (ACE2).
” The observed down-regulation of ACE2 gene expression by a number of tested extracts of brand-new C. Sativa cultivars is a crucial and unique finding,” said the researchers.
” While our most reliable extracts need additional large-scale recognition, our study is necessary for future analyses of the effects of medical marijuana on COVID-19,” composed Olga Kovalchuk and colleagues.
” The down-regulation of ACE2 levels in entrance tissues may thus be a plausible technique for decreasing illness vulnerability,” stated Kovalchuk and coworkers.
According to a report published in the journal News Medical and Life Sciences C. Sativa, especially cultivars rich in cannabidiol (CBD), seems to modify gene expression and have anti-inflammatory and anti-cancer residential or commercial properties.
The scientists identified six extracts that substantially downregulated the expression of ACE2 and 2 extracts that a little upregulated its expression.
In a model of unstimulated oral tissue, two extracts downregulated ACE2 expression, while three other extracts upregulated its expression.
Next, the team took a look at a design of oral tissue that had actually been stimulated by treatment with the inflammatory cytokines tumor necrosis and interferon.
The scientists discovered that all C. Sativa extracts however one downregulated the expression of this altered ACE2 mRNA level.
Furthermore, in a model of inflammation-stimulated 3D intestinal tissues, 2 extracts significantly downregulated ACE2 mRNA levels.
” Using artificial 3D human designs of the oral, airway, and intestinal tract tissues, we identified 13 high-CBD C. Sativa extracts that reduce ACE2 protein levels,” composes the group.
” If these outcomes are further verified, these high-CBD marijuana extracts can be utilized to develop prevention methods directed at decreasing ACE2 levels in high-risk entrance tissues,” they write.
” The extracts of our most successful unique high-CBD C. Sativa lines, pending additional examination, may become a safe and beneficial addition to the prevention and treatment of COVID-19 as an accessory therapy,” concluded the group